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Moeremans I, Devreese M, De Baere S, Croubels S & Hermans K
Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus).

Vet Anaesth Analg, 46(4): 548-555, 2019
ISSN: 1467-2987 Veterinary Anesthesia and Analgesia (PubMed)

Abstract
OBJECTIVE: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. STUDY DESIGN: Prospective crossover study. ANIMALS: A group of six healthy male Dunkin Hartley guinea pigs. METHODS: A single dose of meloxicam (1,5 mg/kg) was administered orally and intravenously (IV) to six healthy male guinea pigs. A wash-out period of 48 hours was taken into account between administrations (oral and IV) in the same animal. Blood was sampled through a central venous catheter before administration (t = 0 hours) and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 and 28 hours post administration. After centrifugation, plasma concentrations of meloxicam were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated using noncompartmental analysis. RESULTS: Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3,7 ± 1,7 hours) and maximal plasma concentration was 0,92 ± 0.30 µg/mL. After IV administration, total body clearance and volume of distribution were 0,13 ± 0.04 and 0,72 ± 0,36 L/kg, respectively. Terminal half-life was 3,7 ± 0,7 hours and 3,5 ± 1,1 hours after IV and oral administration, respectively. Body extraction ratio was 0.0087 and mean absorption time was 3,8 ± 1,7 hours. The absolute oral bioavailability was 0,54 ± 0.14 in unfasted guinea pigs. CONCLUSIONS AND CLINICAL RELEVANCE: This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.

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