Evans WE & Relling MV
Pharmacogenomics: translating functional genomics into rational therapeutics.

Science, 286(5439): 487-491, 1999
ISSN: 0036-8075 Science (PubMed)

Abstract
Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.