Li J, Milne RW, Nation RL, Turnidge JD, Smeaton TC et al
Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration.

Antimicrob Agents Chemother, 47(5): 1766-1770, 2003
ISSN: 0066-4804 Antimicrobial Agents and Chemotherapy (PubMed)

Abstract
The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.