Neil KM, Caron JP & Orth MW
The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals.

J Am Vet Med Assoc, 226(7): 1079-1088, 2005
ISSN: 0003-1488 Journal of the American Veterinary Medical Association (PubMed)

Abstract
Joint disease, in particular osteoarthritis, is an important cause of lameness and debilitation for humans and other animals. Presently, a number of pharmacologic agents are available for treatment for osteoarthritis, including nutraceuticals containing glucosamine and chondroitin sulfate. Although to date clinical trials in veterinary patients are limited, trials conducted in humans have for the most part provided encouraging results. Results of in vitro studies suggest that these compounds may impede the progression of joint degeneration in osteoarthritis. The purpose of this review is to provide veterinary practitioners with up-to-date information regarding the mechanism of action, pharmacokinetics, clinical efficacy, and safety of glucosamine and chondroitin sulfate.