Goulding NJ & Guyre PM
Glucocorticoids, lipocortins and the immune response.

Curr Opin Immunol, 5(1): 108-113, 1993
ISSN: 0952-7915 Current Opinion in Immunology (PubMed)

Abstract
Glucocorticoids are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-1, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation.