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McCaw DL, Miller MA, Ogilvie GK, Withrow SJ, Brewer WG Jr, Klein MK et al
Response of canine mast cell tumors to treatment with oral prednisone.

J Vet Intern Med, 8(6): 406-408, 1994
ISSN: 0891-6640 Journal of Veterinary Internal Medicine (PubMed)

Abstract
Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.

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