Olivero DK, Davidson MG, English RV, Nasisse MP, Jamieson VE et al
Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs.

J Am Vet Med Assoc, 199(8): 1039-1042, 1991
ISSN: 0003-1488 Journal of the American Veterinary Medical Association (PubMed)

Abstract
Keratoconjunctivitis sicca (KCS) is a prevalent and often vision-threatening condition in dogs. In several reports, 2% cyclosporine (cyclosporin A, CsA) was described as effective in modulating the clinical signs of KCS. This study was designed to compare the efficacy of 1% CsA vs a placebo, using a randomized double-blind clinical trial. Topical administration of 1% CsA significantly improved Schirmer wetting values and subjective markers of corneal health as compared with the placebo. In the dogs treated with topical administration of 1% CsA, the clinical signs of KCS were improved in 81.8% of cases.