Bishop BF, Bruce CI, Evans NA, Goudie AC, Gration KAE et al
Selamectin: a novel broad-spectrum endectocide for dogs and cats.

Vet Parasitol, 91(3-4): 163-176, 2000
ISSN: 0304-4017 Veterinary Parasitology (PubMed)

Abstract
Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-av ermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins.