Peterson ME & Graves TK
Effects of low dosages of intravenous dexamethasone on serum cortisol concentrations in the normal cat.

Res Vet Sci, 44(1): 38-40, 1988
ISSN: 0034-5288 Research in Veterinary Science (PubMed)

Abstract
The suppressive effects of three different low dosages of dexamethasone (5, 10 and 15 micrograms kg^-1) on serum cortisol concentrations were evaluated in 10 normal cats. On four different days, serum was collected before and at two, four, six and eight hours after the intravenous administration of saline or dexamethasone. Following the administration of saline, no significant difference in mean serum cortisol concentrations was noted between the basal or postinjection values. In contrast, mean serum cortisol concentrations decreased significantly (P less than 0.05) by two hours and remained significantly below mean basal values eight hours after injection of all three dosages of dexamethasone. The degree of cortisol suppression became progressively greater as the dosages of dexamethasone were increased. After administration of the highest dose of dexamethasone (15 micrograms kg^-1), serum cortisol decreased to below 5 ng ml^-1 by two to four hours and remained suppressed (under 5 ng ml^-1) eight hours after injection in all cats. In contrast, two of the 10 cats showed a slight escape from cortisol suppression by eight hours after injection of dexamethasone at the dosage of 10 micrograms kg^-1, whereas a dosage of 5 micrograms kg^-1 failed to suppress cortisol concentrations below 10 ng ml^-1 at any of the sampling times in one cat and was associated with increasing serum cortisol concentrations at eight hours after injection in three cats. The results of this study indicate that, of the three dosages of three dosages of dexamethasone evaluated in this study, the 15 micrograms kg^-1 dose may be the most reliable consistently to suppress serum cortisol to low or undetectable concentrations, as well as maintain such cortisol suppression at eight hours after injection in the normal cat.