McHardy N, Woollon RM, Clampitt RB, James JA, Crawley RJ et al
Efficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheep.

Res Vet Sci, 41: 14-20, 1986
ISSN: 0034-5288 Research in Veterinary Science (PubMed)

Abstract
An intramuscular dose of 1.2 mg kg^-1 of imidocarb dipropionate (IMDP) was effective in controlling fatal infections with Babesia ovis in sheep. The sheep were infected by the intravenous injection of sheep blood containing B ovis. A severe recrudescence of infection occurred in most sheep 10 to 14 days after therapy but this could be controlled by a second dose of 1.2 mg kg^-1 IMDP. Studies on the toxicology, residues and metabolism of IMDP showed this to be a safe dosage regimen. Transient or mild signs of toxicity were seen at 2.4 and 4.8 mg kg^-1 IMDP. Severe toxicity was observed in sheep treated with 9.6 mg kg^-1.