mdi-book-open-variant Impressum mdi-help Hilfe / Anleitung mdi-printer Webseite ausdrucken mdi-bookmark Bookmark der Webseite speichern mdi-magnify Suche & Index Wirkstoffe mdi-sitemap Sitemap CliniPharm/CliniTox-Webserver mdi-home Startseite CliniPharm/CliniTox-Webserver mdi-email Beratungsdienst: Email / Post / Fax / Telefon

Bryant JE, Brown MP, Gronwall RR & Merritt KA
Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitory concentrations.

Equine Vet J, 32(3): 233-238, 2000
ISSN: 0425-1644 Equine Veterinary Journal (PubMed)

Abstract
The objectives of this study were to determine the pharmacokinetics and tissue concentrations of doxycycline after repeated intragastric administration, and to determine the minimum inhibitory concentrations (MIC) for equine pathogenic bacteria. In experiment 1, 2 mares received a single intragastric dose of doxycycline hyclate (3 mg/kg bwt). Mean peak serum concentration was 0.22 µg/ml 1 h postadministration. In experiment 2, 5 doses of doxycycline hyclate (10 mg/kg bwt), dissolved in water, were administered to each of 6 mares via nasogastric tube at 12 h intervals. The mean ± s.e. peak serum doxycycline concentration was 0.32 ± 0.16 µg/ml 1 h after the first dose and 0.42 ± 0.05 µg/ml 2 h after the fifth dose. The mean trough serum concentrations were ≥ 0.16 µg/ml. Highest mean synovial concentration was 0.46 ± 0.13 µg/ml and highest mean peritoneal concentration was 0.43 ± 0.07 µg/ml, both 2 h after the fifth dose. Highest urine concentration was mean ± s.e. 145 ± 25.4 µg/ml 2 h after the last dose. Highest endometrial concentration was mean ± s.e. 1.30 ± 0.36 µg/ml 3 h after the fifth dose. Doxycycline was not detected in any of the CSF samples. Mean ± s.e. Vdarea was 25.3 ± 5.0 l/kg and mean t1/2 was 8.7 ± 1.6 h. In experiment 3, minimum inhibitory concentrations of doxycycline were determined for 168 equine bacterial culture specimens. The MIC90 was ≤ 1.0 µg/ml for Streptococcus zooepidemicus and 0.25 µg/ml for Staphylococcus aureus. Based on drug concentrations achieved in the serum, synovial and peritoneal fluids and endometrial tissues and MIC values determined in the present study, doxycycline at a dose of 10 mg/kg bwt peros every 12 h may be appropriate for the treatment of infections caused by susceptible (MIC ≤ 0.25 µg/ml) Grampositive organisms in horses.

© 2021 - Institut für Veterinärpharmakologie und ‑toxikologie

Es kann keinerlei Haftung für Ansprüche übernommen werden, die aus dieser Webseite erwachsen könnten.